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(More customer reviews)The term 'systems biology' was coined to describe the field of scientific inquiry which takes a global approach to the understanding of cells and the elucidation of biological processes and mechanisms. It is an integrated approach that brings together and leverages theoretical, experimental, and computational approaches in order to establish connections among important molecules or groups of molecules in order to aid the eventual mechanistic explanation of cellular processes and systems.
This is a field that simply did not exist a decade ago, and is the result of the advent of genome sequencing and associated technologies. This has spurred the development of specialized equipment and sophisticated computer programs that have basically developed into its own specialty as well as affecting virtually all aspects of biology.
This series of two books cover the present state of the art in the field by enlisting specialist writers from literally around the world to contribute chapters based on their own expertise and research. As such these volumes are well in advance of anything that can be written by any single individual.
The editors:
Isidore Rigoutsos is manager of Bioinformatics and Pattern Discovery at IBM.
Gregory Stephanopoulos is Professor of Chemical Engineering and Biotechnology at MIT.
Click Here to see more reviews about: Systems Biology: Volume II: Networks, Models, and Applications (Series in Systems Biology) (v. 2)
The advent of genome sequencing and associated technologies has transformed biologists' ability to measure important classes of molecules and their interactions. This expanded cellular view has opened the field to thousands of interactions that previously were outside the researchers' reach. The processing and interpretation of these new vast quantities of interconnected data call for sophisticated mathematical models and computational methods. Systems biology meets this need by combining genomic knowledge with theoretical, experimental and computational approaches from a number of traditional scientific disciplines to create a mechanistic explanation of cellular systems and processes.Systems Biology I: Genomics and Systems Biology II: Networks, Models, and Applications offer a much-needed study of genomic principles and their associated networks and models. Written for a wide audience, each volume presents a timely compendium of essential information that is necessary for a comprehensive study of the subject. The chapters in the two volumes reflect the hierarchical nature of systems biology. Chapter authors-world-recognized experts in their fields-provide authoritative discussions on a wide range of topics along this hierarchy. Volume I explores issues pertaining to genomics that range from prebiotic chemistry to noncoding RNAs. Volume II covers an equally wide spectrum, from mass spectrometry to embryonic stem cells. The two volumes are meant to provide a reliable reference for students and researchers alike.
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